Isoflurane Fahrenheit Use In Pregnancy & Lactation

Pregnancy: Reproduction studies have been carried out on animals after repeated exposure to anesthetic concentrations of isoflurane. lsoflurane has been shown to have a possible anesthetic-related fetotoxic effect in mice when given in doses six times the human dose. Studies with the rat demonstrated no effect on fertility, pregnancy or delivery or on the viability of the offspring. No evidence of teratogenicity was revealed. Comparable experiments in rabbits produced similar negative results. The relevance of these studies to the human is not known, as there are no adequate and well-controlled studies in pregnant women.
lsoflurane, like other inhalational agents, has relaxant effects on the uterus with the potential risk for uterine bleeding. Clinical judgment should be observed when using isoflurane during obstetric anesthesia. Consideration should be taken to use the lowest possible concentration of isoflurane in obstetrical operations.
Lactation: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when isoflurane is administered to a nursing woman.